Christian Bernard, MD, performed the first successful human heart transplant
in South Africa in 1967. Many patients received heart transplants over the
next 10 years around the world, but unfortunately, few survived.
Survival rates improved in the early 1980’s with the discovery of cyclosporine,
a medicine that keeps the body from rejecting the new heart. Today, more
than 100,000 people have had successful heart transplant surgeries to treat
end-stage cardiac disease. Results continue to improve because of better
medications for the treatment of infection and rejection. The single biggest
limiting factor to transplantation today is the limited supply of donor organs.